online ISSN 2415-3176
print ISSN 1609-6371
logoExperimental and Clinical Physiology and Biochemistry
  • 5 of 8
Up
ECPB 2025, 104(4): 35–42
https://doi.org/10.25040/ecpb2025.04.035
Theoretical medicine

Carcinogenic substances in food: risks to human health

N. O. KRUPKA, U. B. LOTOTSKA-DUDYK, O. M. KOLINKOVSKYI, V. V. LABOYKO, N. M. CHEMERYS
Abstract

Summary. Numerous scientific studies have demonstrated a direct relationship between food quality, dietary habits, and the potential risk of developing oncopathology.

The aim of the work was to analyze the risks associated with chemical substances and food products with proven carcinogenicity for humans, and to identify preventive ways to minimize their effects.

Materials and methods: information search, content analysis, method of theoretical analysis and generalization of scientific information.

Results. Considering that nutrition plays a very important role in sustaining human life, up to 70 % of carcinogens enter the body with food, whereas only 30 % come from air and drinking water. During production, storage, and transportation, food products are increasingly contaminated with substances of chemical and biological origin that either directly exert carcinogenic effects on the body when consumed or are capable of exhibiting such effects under certain conditions. The most dangerous technological processes that are accompanied by the formation and accumulation of carcinogenic substances are smoking and high-temperature frying. Carcinogenic mycotoxins (metabolic products of mold fungi) enter food products as a result of mold parasitism on cereals, legumes, and nuts. Mycotoxins are extremely stable and are not destroyed by heating or culinary processing. Food packaging may also be a source of carcinogenic substances in food products.

Conclusions. Substances of chemical and biological origin with proven carcinogenicity to humans via the alimentary route of exposure were analyzed. The need to increase the overall level of public awareness regarding the role of nutrition as a risk factor in the development of oncological diseases was established. It was demonstrated that an effective preventive measure is the strengthening of supervision and control over technologies for the cultivation, processing, and storage of food products, as well as over the use of food additives and production technologies in the food industry.

Keywords: food products, chemicals, mycotoxins, carcinogenicity, risk

Full text: PDF (Ukr) 207K

References
  1. Jayaraj S, Kothandan L, Murugan VB, Prakash SK, Vijayakumar V, Rani E. Food Toxicology and Safety: Evaluating Dietary Risks and Functional Ingredients. Food Bioengineering, 2025, 4:182-198. doi.org/10.1002/fbe2.70014
  2. Smoliar VI. Modern aspects of food carcinogenesis. Suchasni problemy toksykolohii(in Ukrainian). 2010, 4(31):5-18.medved.kiev.ua/web_journals/arhiv/nutrition/2010/1-2_10/str05.pdf
  3. Chernychenko IO, Balenko NV, Lytvychenko OM, Babii VF, Hlavachek DO, Kondratenko OY. Impact of some environmental chemical carcinogens on the incidence of hormone-dependent tumors and possible mechanisms of its realization (literary review). Environ Amp Health. 2021. 99(2):44-55. doi.org/10.32402/dovkil2021.02.044
  4. Chernichenko IO, Babii VF, Litvichenko OM, Kondratenko OY, Balenko NV, Hlavachek DO. Іdentification of non-carcinogenic risks from oral intake of priority chemicals in the organism. Hyg Popul. 2019, (69):88-95. doi.org/10.32402/hygiene2019.69.088
  5. Chernychenko IO, Lytvychenko OM, Sovertkova LS. Carcinogens in food, hazard assessment. Hihiiena naselenykh mists. (in Ukrainian). 2013, 61:156-163.nbuv.gov.ua/UJRN/gnm_2013_61_26
  6. Bulanda S, Szumska M, Nowak A, Janoszka B, Damasiewicz-Bodzek A. Determination of Polar Heterocyclic Aromatic Amines in Meat Thermally Treated in a Roasting Bag with Dried Fruits. Foods. 2025, 14(4):559. doi.org/10.3390/foods14040559
  7. Seyyedsalehi MS, Mohebbi E, Tourang F, Sasanfar B, Boffetta P, Zendehdel K. Association of dietary nitrate, nitrite, and n-nitroso compounds intake and gastrointestinal cancers: a systematic review and meta-analysis. Toxics. 2023, 11(2):190.doi.org/10.3390/toxics11020190
  8. Abdel-Shafy HI, Mansour MS. A review on polycyclic aromatic hydrocarbons: Source, environmental impact, effect on human health and remediation. Egypt J Pet 2016, 25(1):107-23.doi.org/10.1016/j.ejpe.2015.03.011
  9. Agyei TA, Amponsah SK, Akowuah JO, Addo A. Polycyclic aromatic hydrocarbon profiles and carcinogenic risks associated with smoked catfish and rabbit meat: a comparative study of traditional and improved smoking methods. J Food Qual. 2025,1:1-10. doi.org/10.1155/jfq/8759400
  10. Huybrechts I, Jacobs I, Biessy C, Aglago EK, Jenab M, Claeys L, et al. Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort. PLOS ONE. 2024, 19(12):e0315561. doi.org/10.1371/journal.pone.0315561
  11. Abi Rizk M, Nehme L, Snini SP, Hassan HF, Mathieu F, El Rayess Y. Mapping Global research trends on aflatoxin m1 in dairy products: an integrative review of prevalence, toxicology, and control approaches. Foods. 2026, 15(1):166. doi.org/10.3390/foods15010166
  12. Bayode M, Oguntuase S, Akinbami B. Navigating the aflatoxin and cyanide challenge in traditionally-processed garri: a mechanistic review of cyanide-aflatoxin trade-off, balancing contamination reduction and food safety risks. Bull Natl Res Cent. 2025, 49:83. doi.org/10.1186/s42269-025-01379-3
  13. Souroujon AA, Sundaresan V, Golos A, Leapman M, Gomez-Santamaría OA, Casilla-Lennon M. The role of nutrition in prostate cancer risk, progression, and mortality: a comprehensive review. 2026, 9:102914. doi.org/10.1016/j.clnesp.2026.102914
  14. Nambiar VK, Mudliar V, Salababa I. Analysis of oral cancer carcinogens in repeatedly heated cooking oils. Heliyon. 2025, 11(2):e41858. doi.org/10.1016/j.heliyon.2025.e41858
  15. Parkinson LV, Geueke B, Muncke J. Potential mammary carcinogens used in food contact articles: implications for policy, enforcement, and prevention. Front Toxicol 2024 6, 1440331. doi.org/10.3389/ftox.2024.144033


Програмування - Roman.im | QR-Code Generator