The number of patients suffering from ulcer disease is continuously rising and registered 160 cases per 1 000 of population in Ukraine. Stomach resection is the method of choice for complicated ulcer disease treatment. The connection between digestive diseases and diseases of musculoskeletal system is well known. The stomach resection is an important factor of secondary osteoporosis development, although the pathogenesis of this process has not been studied enough. The comprehensive analysis of the pathological changes of musculoskeletal system in late terms after stomach resection was conducted for the first time and presented in the article.

To investigate the features of hormonal and metabolic homeostasis in men with secondary osteoporosis after stomach resection caused by complicated ulcer disease.

The research was based on the examination of 164 men of middle and old age with secondary osteoporosis after stomach resection caused by complicated ulcer disease. The control group IA was represented by 31 healthy men. 26 men who were not diagnosed with osteoporosis after stomach resection caused by complicated ulcer disease were included to the control group IB. The structural and functional state of bone tissue and the features of hormone-metabolic homeostasis were discovered in these patients.

In the majority of scheduled operated patients in late terms after resection of the stomach due to complicated peptic ulcer disease, accompanied affection of the bone tissue which leads to generalized osteoporosis was revealed. The complex analysis of the pathological changes of musculoskeletal system in late terms after stomach resection showed that stomach resection has an important influence on hormonal and metabolic homeostasis and on osteoporosis development.

these patients: increased of all investigational catabolic hormones, except glucagon, decreased of all investigational anabolic hormones, except testosteron, reduced cyclic nucleotides concentration. The electrolyte homeostasis complex analysis revealed the following disturbances: the levels of the ionized calcium (0.900±0.008 mmol/l; p<0.001in comparison with results of control groups IA and IB), phosphorus (0.58±0.09 mmol/l; p<0.05) and magnesium (0.3±0.1 mmol/l; p<0.05) were lower, although the level of total calcium was not significantly different from the results of control groups IA and IB. We found the protein disorders: hypoalbuminemia with hyper-α1-globulinemia and hyper-β- globulinemia, although the level of total protein in the majority of scheduled operated men was not statistically different from the results obtained in control groups IA and IB. Consequently, hormonal and metabolic homoeostasis features in the majority of scheduled operated men with secondary osteoporosis after stomach resection caused by complicated ulcer disease have their own characteristics: electrolyte and protein homeostasis regulating hormones violation, electrolyte disturbances and protein disorders. In our opinion these scientific facts play an important role in pathogenesis of osteoporosis in men after stomach resection and will help in treatment of secondary osteoporosis and prevention of its complications.

Keywords: osteoporosis, stomach resection, ulcer disease, hormonal and metabolic homeostasis

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