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ECPB 2013, 62(2): 22–29
Experimental physiology and biochemistry

Fatty acid composition of phospholipids of the blood plasma and tissues of rabbits with acute arginine pancreatitis and its correction

HOPANENKO O., RIVIS Y.
Abstract

The subject matter of the present study was the level of phospholipids and fatty acid composition of phospholipids in the blood plasma, liver and skeletal muscles of rabbits with acute arginine pancreatitis and its correction by linseed oil.

The pancreas plays an important role in the exchange of lipids and fatty acids in humans and animals. Nutritional and chemical factors affect the functioning of the pancreas and its secretion of enzymes and hormones. However, the class of lipids such as phospholipids and their fatty acid composition form the cell membranes and the plasma membranes of humans and animals. The functional state of cell membranes and transport ability of the plasma membranes depend on the contents of phospholipids and their fatty acid composition. Furthermore, phospholipids of blood plasma, liver and skeletal muscles, which are rich in polyunsaturated fatty acids of omega-3 and omega-6 families, are the source for the synthesis of biologically active substances with a very wide range of actions – eicosanoids (prostaglandins, thromboxanes and leukotrienes).

It was found that the content of phospholipids unchanged in the blood plasma, liver and skeletal muscle of rabbits with acute arginine pancreatitis and rabbits with acute arginine pancreatitis corrected by using linseed oil. Saturated and monounsaturated fatty acids predominate in fatty acid composition of phospholipids of the blood plasma, liver and skeletal muscles of rabbits with acute arginine pancreatitis. It may indicate deterioration in the structural organization and functional capacity of plasma and cell membranes. In the other way, predominance of polyunsaturated fatty acids in the fatty acid composition of phospholipids in the above mentioned fluid and tissues is observed at acute arginine pancreatitis corrected by using linseed oil. It may give evidence to improvement of structural organization and functional capacity of plasma membranes and cell membranes.

In acute arginine pancreatitis the concentration of polyunsaturated fatty acids in the phospholipid fatty acid composition of blood plasma, liver and skeletal muscles is reduced by fatty acid families omega-3 and omega-6. At the same time the ratio of polyunsaturated fatty acids of omega-3 family to polyunsaturated fatty acids of the omega-6 family decreases in the fatty acid composition of phospholipids of blood plasma, liver and skeletal muscles of rabbits. By feeding with linseed oil the relative amount of polyunsaturated fatty acids in the phospholipid fatty acid composition of blood plasma, liver and skeletal muscles is increased by fatty acids of omega-3 family. And the ratio of polyunsaturated fatty acids of the omega-3 family to polyunsaturated fatty acids of the omega-6 family grows.

Also it was found that the amount of more long-chain and more unsaturated derivatives of linoleic and linolenic acids decreases in phospholipid fatty acid composition of blood plasma, liver and skeletal muscles of rabbits with the acute arginine pancreatitis.

The amount of the latter becomes normal in the fatty acid composition of phospholipids of blood plasma, liver and skeletal muscle of rabbits with acute arginine pancreatitis corrected by linseed oil.

Keywords: rabbits, pancreatitis, correction, phospholipids, fatty acid composition

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