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ECPB 2013, 62(2): 56–61
Clinical physiology and biochemistry

Condition of the bone tissue associated with age morphofunctional changes of parathyroid glands


The problem of osteoporosis development while diagnosing the pathology of parathyroid glands has caused the profound studying of bone tissue metabolism. But the morphofunctional peculiarities of bone tissue along with changes in the composition of parathyroid glands and associated with mineral exchange depending upon gender can rarely be found in literature.

The work aimed to conduct a comparative analysis of the bone tissue condition associated with the morphology of parathyroid glands in age aspect and depending upon gender.

Autopsy material from parathyroid glands and bone tissue (from the anterior superior ileac spine) of men and women of different age groups has been received in Lviv pathoanatomical bureau in the course of performing current dissections. In the anamnesis and pathologist’s report there have been no diseases which could have influenced the results of investigations conducted. All the material has been divided into four age groups: the first group (30–44 years old), the second group (45–59 years old), the third group (60–74 years old), the forth group (75–90 years old), men (n=20) and women (n=20) separately.

The morphometric investigations concerning quantitative ratio between principal and oxyphil parathyrocytes, their average diameter and the determination of nuclei volume of parathyrocytes as well as the thickness of the cortical layer and trabecules in bone tissue have been held. Calcium, phosphorus and magnesium content in bone tissue have been detected, and parahormone level has been determined in heparinized blood plasma of 77 conditionally healthy people. The results have been worked out statistically.

Nuclei volume expansion of the principal parathyrocytes associated with decreasing number of these cells in the parenchyma of parathyroid glands of women of 60–74 years old and of 75–90 years old has been shown. Men as well as women of the forth age group have had the same level of the relative number of parathyrocytes with the largest and the smallest content of nucleic acids in their nuclei. The decrease in width of the cortical and trabecular layers of the iliac bone process in women of the third and forth groups along with the increase of the volume of the principal parathyrocytes’ nuclei and their content of nucleic acids what indicates the possibility of intensification the parathyroid glands’ influence on the intensity of catabolism processes in remodeling bone tissue with age has been stated.

In men the increase in width of the cortical layer in the second and third age groups and significant decrease of this index in the forth group has been accompanied by the gradual drop of the weight content of calcium in bone tissue. The content of phosphorus in men has been decreasing at first though in the third and forth groups it has been somewhat increasing, while in women of all groups under study this index has been growing. In both sexes at first the increase of magnesium content in bone tissue of iliac bone process with subsequent decrease of this index in forth group of men and women has been marked.

Keywords: bone tissue, parathyroid, morphometry

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