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ECPB 2013, 62(2): 96–100
Assisting a doctor

Clinical changes and dynamics of microflora in patients with irritable bowel syndrome

MERENTSOVA O.
Abstract

Irritable Bowel Syndrome (IBS) possess leading position among functional diseases of digestion. It is near 10–20% among the adult population. IBS is diagnosed by using Rome III: when a person has abdominal pain or discomfort at least three times per month for the last 3 months without other disease or injury that could explain the pain. The pain or discomfort of IBS may occur with a change in stool frequency or consistency or may be relieved by bowel movement.

IBS is often classified into four subtypes based on the person’s usual stool consistency.

These subtypes are important because they affect the types of treatment that are most likely to improve the person’s symptoms. The four subtypes of IBS are:

• IBS with constipation (IBS-C) hard or lumpy stools at least 25 percent of the time, loose or watery stools less than 25 percent of the time.

• IBS with diarrhea (IBS-D) loose or watery stools at least 25 percent of the time, hard or lumpy stools less than 25 percent of the time.

• Mixed IBS (IBS-M) hard or lumpy stools at least 25 percent of the time, loose or watery stools at least 25 percent of the time.

• Unsubtyped IBS (IBS-U) hard or lumpy stools less than 25 percent of the time, loose or watery stools less than 25 percent of the time.

According to the contemporary opinions IBS is a result of a failure of biological and psychosocial factors. Condition of the intestinal microflora has it’s important role in the development if this disease too.

Contemporary treatment is directed to all links of the pathological process, that is why it is hard for the doctors to avoid polypragmasy. As far as dysbios is one of main factors of IBS the treatment should also include medicine that has influence on normalization of intestinal microflora.

The aim of the work was to research intestinal microflora and clinical changes in patients with diarrhea and constipation types of Irritable Bowel Syndrome.

50 patients were examined. The diagnosis of IBS was defined according to the Rome III Criteria. Patients were divided into two groups- Constipation type of IBS (24 persons) and Diarrhea type of IBS (26 persons). The diagnostic and estimating the results of the treatment were conducted using the questionnaire.

Besides the classic treatment of the IBW patients were using Lacium twice a day per two weeks. Microbiological tests of gut of the patients were made according to the existent methodical recommendations.

Results that were received showed strong changes of indexes of intestinal microflora. The main role in the formulation of dysbiosis belong to the decrease of the level of basic normal symbiots (Bifidobacterium, Lactobacterium, ect) instead of the growth of pathogenic microflora (Proteus, Citrobacter, Klebsiella, Escherichia, Candida). Stronger alterations of intestinal microflora were in the group of diarrhea type patients.

Intestinal dyspepsia was actually in all of the patients in two groups before treatment and after using Lacium it disappeared or considerably decreased.

Intestinal dyspepsia was actually in all of the patients in two groups before treatment. The main role in the formulation of dysbiosis belong to the decrease of the level of basic normal symbiots instead of the growth of pathogenic microflora.

The safety of using in treatment such medicine as Lacium was determined. It is showed that this medicine is effectual in eliminating symptoms of intestinal dyspepsia and has positive influence on bowel microflora.

Keywords: Irritable Bowel Syndrome, Intestinal Microflora

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