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ECPB 2015, 71(3): 98–104
Literature review

Modern anabolic agents and prospects thiazolidоne derivatives as a new class


Anabolic means accelerating the update and the formation of structural parts of cells and tissues mainly due to regeneration and stimulation of protein synthesis.

The aim of the study was a review of scientific literature sources on modern approaches to the modulation of anabolic pharmacology and prospects thiazolidine derivatives as their new class.

Analysis of the literature found term use for research and development of anabolic agents, despite their androgenic effects on the human body. The problem of finding a universal anabolic activity with maximum and minimum androgenic action remains open and timely.

The spectrum of therapeutic use of anabolic drugs at a broad-cachexia, infectious diseases, muscular dystrophy, burns, injuries, fractures, atrophy, cancer and other diseases. Despite the enormous potential pharmacological anabolic drugs, the key problem is the issue of side effects with prolonged use them.

Considering the negative side effects and social aspects of the use of drugs and hormones anabolic steroids considerable attention pharmacological science focused search and create an anabolic drugs nonsteroidal structure with equivalent effect parameters improved bioavailability and toxicity. It should be noted also very costly process for anabolic steroid drugs because of the special uniqueness of their chemical structure. At the same time, a clear direct effect on myocardial processes or osteoanabolizmu these drugs do not show.

A possible way to find new anabolic agents is to study molecular structures and functions of known nuclear receptors and ligands specific search for them. These ligands are derived classic 4-tiazolidynonu that exhibit antibacterial, antifungal, anti-inflammatory, antitumor, antiviral and antioxidant effects.

Noting survey work, it can be argued that the modulation of androgen (nuclear) receptor is a key strategy impact on anabolism pharmacological agents, including derivatives 4 tiazolinynonu who possess a high level of anabolic activity and bioavailability satisfactory parameters.

An important aspect of the pharmacological effects of 4-tiazolidynonu compounds are characterized by distinct antioxidant effect, which is often combined with the main activity, and often antioxidant effect is desirable and necessary for cellular anabolism. Another no less important medical and social problem is the alimentary dystrophy, which are more characteristic of the population of the Third World and also require therapeutic correction aimed at anabolism. Against the background of such a gigantic need for effective anabolic preparations number of scientific – practical research and development on this subject is extremely small. Over the past 25 years (from 1989 to 2014) in "Pharmacologicalreviews" published only two fundamental literary reviews, which are indirectly deal with these research and development of anabolic drugs and are devoted to studying the properties and pharmacological potential nuclear (nuclear) receptors and their synthetic ligands.

Modern high-performance and highly anabolic drugs are relevant and necessary to medicine. Significant prospects for the discovery of new compounds with high anabolic activity and satisfactory bioavailability parameters opens in-depth screening of 4-tiazolidynon.

Keywords: anabolism, thiazolidоne, retabolil, testosterone propionate

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