Nowadays ulcerous disease in Ukraine is one of the most widespread illnesses of digestion system, almost 50 % of gastroenterology patients in municipal hospitals are patients with the ulcerous defeats of stomach and duodenum.

Inadequate treatment of ulcerous disease results in different types of complications, which in the most cases threaten the life of a patient. Literature data testify convincingly, that mostly ulcerous diseases that do not associate with Helicobacter pylori infection can be related to influence of stress on the human organism. Infecting with the Helicobacter pylori infection worsens flowing of ulcerous disease, pathogenesis of which is related to different factors: an ulcerous defect heals slower and duration of remission periods diminishes. Really, modern society is characterized by all greater distribution of the so called "illnesses of civilization", nosotropic basis of which is emotional stress. Thus chronic unfavorable influences, which are tested by human organism in the conditions of the technogenic pressing, social instability, tension of life rhythm can be both main and additional etiologic factor of many diseases. At the terms of action of stress functional backlogs of organism go down, ability of human organism for adaptation diminishes, and maintenance of homoeostasis comes true due to considerable tension of the regulator systems. Previously, we have shown that daily introduction of monosodium glutamate to the rats in a dose 15 and 30 mg/kg (1 and 2 gr / average man) during 30 days causes hyper secretion, development of damage (hemorrhages, erosions and ulcers) in the mucous membrane of stomach. That is why, in this work we decided to investigate influence of the protracted introduction of monosodium glutamate on firmness of mucus membrane of the of rats’ stomach under the action of stress. In our view realization of such researches is expedient in connection with growing morbidity rate related with digestion disorder diseases, especially that part of population, that feeds in the "fast food" restaurants (that use food additives).

In this connection, the aim of the work was to learn the influence of 30 days introduction of monosodium glutamate on the mucus membrane of the stomach of rats under stress conditions.

The monosodium glutamate was dissolved in 0.5 ml of water. The stress damages of stomach mucous membrane were caused by the widespread method of water immersion stress. For the analysis of the structural changes in mucous membrane of the stomach, animals were euthanized, after that we examined the stomach, cut it in small curvature, turned inside out the mucous membrane outside and carefully washed by a solution. Where upon the gastro scope at transluminal magnifying glass (х4) we counted up the amount and the area of ulcers, length of erosions on the average on one stomach in every group of rats. It was established that long-term treatment of monosodium glutamate for 30-days in doses 15 to 30 mg/kg caused not only injury (hemorrhage, erosions and ulcers) of gastric mucosa, but increased the effect of stress on the mucous. Thus, long-term treatment of food additive monosodium glutamate has broken and exhausted local multi-component stress-limitative system and reduced the protective mechanisms of the body.

Keywords: Monosodium glutamate, stress, gastric ulcers

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