The aim of research was еvaluate the effectiveness of our developed innovative complex combination treatment (with a combination of medication, nutritiological, hirudo and manual therapy) in patients with non-motorized symptoms of Parkinson's disease through the study of the the objective status of the patients on scales Non-Motor Symptoms Scale (NMSS) and endothelial dysfunction of patients. The authors therefore developed and applied innovative original complex combination treatment of non-motor symptoms of Parkinson's disease (the methods include -hirudoterapiya, -nutritiological correction of the food, -manualterapy.

Patients ate on the principles of modern concepts of nutrition, compliance with which was strictly required for all patients: 1. Rol saturation antioxidant diet to update the body. 2. value "ballast" in the diet. 3. Features of the "free mode" with regard to eating human biorhythms approach of sustainable hunger. 4. Necessity separate power supply. 5. The concept of specific food and need periodic cleaning (for treatment of digestive 3rd) starvation. Leeches were applied to areas of the upper Kreninha fields, paravertebral at the seventh cervical vertebra (spinal position often narrowing arteries passing holes) – paravertebral at first coccygeal vertebra, the point of projection stylomastoideum holes in the occipital region, – between vertebras 2nd, 3rd, 4th, 5th cervical vertebrae – between neural sprouts fourth and fifth cervical vertebras, and in the projection of foramen magnum in the middle. Manual therapy performed in stages: 1. Pneumovakuum massage performed according to our methodology. Vacuum banks pushed to the caudal direction to the lower back at an angle a few degrees from the spine to reduce swelling and stagnation in the vertebral segments moving in osteochondrosis and avoid high blood pressure. 2. After postisometric relaxation (at least 10 strains without making inclinations) and pneumovakuum massage started to implement the mobilization and manipulation. 3. The method used have a head tilt and opposition hands physician at the height of tension and traction in a sitting position, which considered safer. The paper examined the endothelial dysfunction is analyzed through a simple and informative method of ultrasonic flow registration vasodilatation of peripheral arteries before and after the ischemic limb, which is considered an integral criterion for evaluating the balance of endothelial substances without requiring complex biochemical definition of numerous vasoactive substances in the blood. Violation of the dilatation (depanding on the blood flows) of the brachial artery considered today as risk factor for non-motor symptoms of Parkinson's disease. The efficiency of the restoration of endothelial function after combined treatment is proved. Given the recovery of the objective status of the patients on scales Non-Motor Symptoms Scale (NMSS) and endothelial dysfunction after combined treatment applied and the objective of the patient may be recommended a specified therapeutic technique for the treatment of non-motorized symptoms of Parkinson's disease and its progression suspension to improve the effectiveness of existing treatment regimens for studied pathology.

Keywords: Parkinson's disease, endothelial dysfunction, nutrition correction, hirudotherapy, manual therapy

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