online ISSN 2415-3176
print ISSN 1609-6371
logoExperimental and Clinical Physiology and Biochemistry
  • 2 of 10
ECPB 2018, 81(1): 11–26
Research articles

Immediate responses of the autonomic nervous system to the balneofactors, their neuro-endocrine-immune accompaniments and predictors


Introduction. In previous studies it has been shown that in response to the intake of Bioactive Water Naftussya (BAWN) the activity of the autonomic nervous system changes and the vector of the reaction is ambiguous. However, the issue of the specificity of immediate effects of BAWN on the nervous as well as endocrine and immune systems is still relevant. This is the objective of this study.

Material and Methods. The object of the observation was 15 volunteers-men (aged 26÷60, M±SD: 44±12 years) without any clinical diagnose but with a moderate dysfunction of neuroendocrine- immune complex (dysadaptation). At the beginning volunteers filled in a questionnaire with the purpose of estimationing the level of the trait anxiety. Then HRV and EEG were recorded. The content of principal adaptation hormones such as Cortisol, Testosterone and Triiodothyronine as well as parameters of Immunity were determined in blood. After registration 5 volunteers of the basic level consumed some days 200 mL of Control Water (distillated, filtered, well), Water Naftussya from layers Truskavets’ and Skhidnyts’a while 10 volunteers consumed 5 mL of Phytocomposition ‘Balm Cryms’kyi’ (it is identified as an adaptogen) soluted in 195 mL of daily Water. all tests were repeated in an hour and a half.

Results. It has been confirmed that the polyvariant nature of the vegetotropic reactions to the balneofactors, namely Bayevskiy’s Stress Index has increased in half of the observations, while in 39% it has decreased and only in 11% has not changed significantly. No differences were found between the effects of all applied stimuli. The method of discriminant analysis revealed 27 parameter change which are characteristic of vegetotropic reactions (Baevskiy’s Stress Index, 3 parameters of HRV, 15 of EEG and 7 of Immunity as well as Testosterone). It has been revealed that initial parameters (2 of HRV, 21 of EEG and 8 of Immunity as well as trait anxiety) allowed to predict each of the three variants of the vegetotropic reaction accurately. Conclusion. The vector of the vegetotropic reaction as well as its absence, is not due to the properties of the stimulus, the time of the use of the balneofactor, but to the state of autonomic reactivity of a person.

Recieved: 01.03.2018

Keywords: balneofactors, neuroendocrine-immune complex, immediate reactions

Full text: PDF (Eng) 499K

  1. 1. Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001;3:106-27.
  2. 2. Balanovs'kyi VP, Popovych IL, Karpynets' SV. About ambivalence-equilibratory character of influence of curative water Naftussya on organism of human [in Ukrainian]. Dopovidi ANU. Matematichni, pryrodnychi, tekhnicni Nauky. 1993;3:154-8.
  3. 3. Barylyak LG, Malyuchkova RV, Tolstanov OB, Tymochko OB, Hryvnak RF, Uhryn MR. Comparative estimation of informativeness of leucocytary index of adaptation by Garkavi and by Popovych. Medical Hydrology and Rehabilitation. 2013;11(1):5-20.
  4. 4. Berntson GG, Bigger JT, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997;34:623-48.
  5. 5. Bilas VR, Popovych IL. Role of microflora and organic substances of water Naftussya in its modulating influence on neuroendocrine-immune complex and metabolism [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009;7(1): 68-102.
  6. 6. Chebanenko OI, Chebanenko LO, Popovych IL. Variety Balneoeffects of Factors Spa Truskavets' and their Forecast [in Ukrainian]. Kyiv: UNESCO-SOCIO: 2012. 496p.
  7. 7. Dats'ko OR, Bubnyak AB, Ivassivka SV. The organic part in mineral water Naftussya. Development of knowledges about its composition and origination [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008;6(1):168-174.
  8. 8. Douglas SD, Quie PG. Investigation of Phagocytes in Disease. Churchil. 1981. 110p.
  9. 9. Gumega MD, Levyts'kyi AB, Popovych IL. Balneogastroenterology [in Ukrainian]. Kyiv: UNESCO-SOCIO. 2011. 243p.
  10. 10. Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996;93(5):1043-1065.
  11. 11. Ivassivka SV. Biological Active Substances of Water Naftussya, their Genesis and Mechanisms of Physiological Effects [in Ukrainian]. Kyiv: Naukova dumka. 1997. 110p.
  12. 13. Klecka WR. Discriminant Analysis [trans. from English in Russian] (Seventh Printing, 1986). In: Factor, Discriminant and Cluster Analysis. Moskwa: Finansy i Statistika. 1989: 78-138.
  13. 14. Kozyavkina NV, Gozhenko AI, Barylyak LG, Korolyshyn TA, Popovych IL. Variety immediate thyrotropic effects of bioactive water Naftussya, their neuroendocrine-immune accompaniment and possibility of forecast [in Ukrainian]. Medical Hydrology and Rehabilitation. 2013;11(4):27-54.
  14. 15. Kozyavkina OV, Kozyavkina NV, Gozhenko OA, Gozhenko AI, Barylyak LG, Popovych IL. Bioactive Water Naftussya and NeuroEndocrine-Immune Complex [in Ukrainian]. Kyiv: UNESCO-SOCIO. 2015. 349p.
  15. 16. Kozyavkina OV, Popovych IL, Zukow W. Immediate vegetotropic effects of bioactive water Naftussya and their neuro-endocrine-immune accompaniment in healthy men. Journal of Health Sciences. 2013;3(5):391-408.
  16. 17. Lapovets' LY, Lutsyk BD. Handbook of Laboratory Immunology [in Ukrainian]. L'viv: 2002. 173p.
  17. 18. Newberg AB, Alavi A, Baime M, Pourdehnad M, Santanna J, d'Aquili E. The measurement of regional cerebral blood flow during the complex cognitive task of meditation: a preliminary SPECT study. Psychiatry Research: Neuroimaging Section. 2001;106:113-22.
  18. 19. Panasyuk YM, Levkut LH, Popovych IL, Alekseyev OI, Kovbasnyuk MM, Balanovskyi VP. Experimental study of adaptogenic properties of 'Crimean' balm [in Ukrainian]. Fiziol Zh. 1994;40(3-4):25-30.
  19. 20. Petsyukh SV, Petsyukh MS, Kovbasnyuk MM, Barylyak LG, Zukow W. Relationships between Popovych's Adaptation Index and parameters of ongoiging HRV and EEG in patients with chronic pyelonephrite and cholecystite in remission. Journal of Education, Health and Sport. 2016;6(2):99-110.
  20. 21. Popovych IL. Functional relationships between parameters of neuro-endocrine-immune complex at male rats [in Ukrainian]. Achivements of Clinical and Experimental Medicine. 2008;2(9):80-7.
  21. 22. Popovych IL. Stresslimiting Adaptogene Mechanism of Biological and Curative Activity of Water Naftussya [in Ukrainian]. Kyiv: Computer press: 2011. 300p.
  22. 23. Popovych IL, Ivassivka SV. Role of organic substances of water Naftussya in its physiological activity [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009;7(2):6-26.
  23. 24. Popovych IL, Kozyavkina OV. Term vegetotropic effects bioactive water Naftussya and their neuro-endocrine-immune accompaniment in apparently healthy men [in Ukrainian]. Medical Hydrology and Rehabilitation. 2012;10(3):32-65.
  24. 25. Popovych IL, Kozyavkina OV, Kozyavkina NV, Korolyshyn TA, Lukovych YS, Barylyak LG. Correlation between Indices of the Heart Rate Variability and Parameters of Ongoing EEG in Patients Suffering from Chronic Renal Pathology. Neurophysiology. 2014;46(2):139-48.
  25. 26. Popovych IL, Lukovych YS, Korolyshyn TA, Barylyak LG, Kovalska LB, Zukow W. Relationship between the parameters heart rate variability and background EEG activity in healthy men. Journal of Health Sciences. 2013;3(4):217-40.
  26. 27. Popovych IL, Ruzhylo SV, Ivassivka SV, Aksentiychuk BI. (editors). Balneocardioangiology [in Ukrainian]. Kyiv: Computerpress. 2005. 229p.
  27. 28. Popovych IL, Vis'tak HI, Gumega MD, Ruzhylo SV. Vegetotropic Effects of Bioactive Water Naftussya and their Endocrine-Immune, Metabolic and Hemodynamic Accompaniments [in Ukrainian]. Kyiv: UNESCO-SOCIO; 2014. 163p.
  28. 29. Practical psychodiagnostics. Methods and tests [in Russian]. Samara: Publing House Bakhrakh; 1998:59-64.
  29. 30. Shannon CE. Works on the theory of informatics and cybernetics [transl. from English to Russian]. Moskwa: Inostrannaya literatura; 1963. 329p.
  30. 31. Vovchyna YV, Lukovych YR, Matiyishyn GY, Hryvnak RF, Tymochko OO, Andrusiv OV, Burkovs'ka MM. Hemodynamic variants term effects of bioactive water Naftussya on blood pressure, their electrolyte accompaniment and the ability to forecast [in Ukrainian]. Medical Hydrology and Rehabilitation. 2013;11(3):50-9.

Програмування -