online ISSN 2415-3176
print ISSN 1609-6371
logoExperimental and Clinical Physiology and Biochemistry
  • 7 of 12
Up
ECPB 2018, 82(2): 49–55
https://doi.org/10.25040/ecpb2018.02.049
Research articles

The Influence of Iodine on the Indicators of Lipid Metabolism in the Blood of White Female Rats of Different Age with Obesity

N. KOPCHAK, О. POKOTYLO, I. NAZARKO, H. BILETSKA1, M. KOVAL2
Abstract

The article begins with a description of influence of thyroid hormones on lipid metabolism, lipid profile and body weight. Prolonged iodine deficiency leads to hypothyroidism which causes serious metabolic disorders. It is important to note that thyroid pathology as well as overweight is more common for women and depends on also on the age. The age features of lipid profile of female rats are described in the paper. A detailed analysis of iodine influence on cholesterol, triacylglycerols and lipoproteins of high and low density has been also described in the article.

The paper aims at the research of the comparative effect of biologically active iodine in the composition of ″Jodis-Concentrate″ and inorganic iodine (KJ) as a component of ″Yodomarine″ on the lipid profile of female rats with experimental alimentary obesity.

Experimental alimentary obesity have been investigated during 45 days at 48 Wistar white female-rats of different age. They have been divided into three groups of 16 animals each. Each group has been divided into 4 subgroups. The control subgroup has undergone a standard diet. Rats of 2, 3 and 4 have had EAO which has consisted of sodium glutamic acid in a ratio of 0.6: 100.0 and a high-calorie diet that has included standard food (47 %), sweet concentrated milk (44 %), corn oil (8 %) and vegetable starch (1%). The 3rd subgroup has been under the effect of biologically active iodine Jodis-Concentrate and 4th - inorganic iodine as potassium iodide in the medicine ″Yodomarine″. The following parameters of lipid profile have been measured by the spectrophotometric method: triacylglycerols, cholesterol, high and low density lipoproteins. The results of the studies show the differences of the content of cholesterol, triacylglycerols and lipoproteins of high and low density in the blood serum of 3, 4, and 6.5 month old females of clinically healthy white rats and EOA animals, that have intragastrically got biologically active Jodis-Concentrate (J-C) and inorganic iodine ″Yodomarine″ (IM).

It has been found that the intragastric administration of ″Jodis-Concentrate″ to the 3, 4 and 6.5 month old females of white rats with EAO (in the 3rd subgroup) has led to a significant decrease of cholesterol level in the blood serum: 15 %; 15.5 % and 17.4 % respectively; while the use of ″Yodomarin’ (in the 4th subgroup) has meant 11.8 %; 14.8 % and 16 %, compared with the same indicator of EAO animals (in the 2nd subgroup) of the corresponding age groups. It has been also found that the concentration of LDL-C in serum blood of 4th and 6.5 month old females of white rats in the control subgroup have been 12.5 and 14.3 % that is significantly higher than in the 3 month old animals. The level of LDL-C in the female white rats with EAO of 3, 4 and 6.5 months has been 36.4; 22.6 and 26.5 % that is much higher than the concentration of LDL-cholesterol in the animals from the control subgroup.

Consequently, it proves the fact that iodine plays an important role in lipid metabolism. The research shows normalization of high-density lipoprotein and triacylglycerol levels. A significant decrease of LDL-cholesterol in each subgroup has been also pointed out.

Article recieved: 11.05.2018

Keywords: blood serum, cholesterol, triglycerides, lipoproteins, ″Jodis-Concentrate″, ″Yodomarine″, obesity, female rats

Full text: PDF (Ukr) 267K

References
  1. 1. Vladymyrova IM. Pharmacotherapeutic directions of application of iodine-containing medicinal plants in different groups of diseases of the thyroid gland. Scientific Journal ′′ScienceRise′′. 2015;11:46-54. doi: 10.15587/2313-8416.2015.54987.
  2. 2. Voronenko NYu. Metabolic syndrome and dysfunction of adipose tissue in women. Women's Health. 2013;5:66-71.
  3. 3. Dolaychuk OP, Fedoruk RS, Kovalchuk ІІ, Kropyvka SY, Tsap MM. Influence of iodine administration on the diet of females and males of rats on physiological parameters of the organism and histology of the thyroid gland. Scientific Herald of the Lviv National University of Veterinary Medicine and Biotechnology SZ Gzhytsky. 2014;2:106-12.
  4. 4. Kalynovskaya EI, Kuznecova IV, Khapalyuk AV, Kondrashova SB, Pavlovets LV, Blahun EV et al. Morphological features of the defeat of the microcirculatory channel and the character of the change in the level of the hormone of fatty tissue of visfatin in rats on the model of alimentary obesity. Journal of the Grodno State Medical University. 2015;4(52):48-53.
  5. 5. Nedoshytko KhYu, Pokotylo OS. Lipid profile of blood of white rats of different sex under xenobi- otic intoxication and with correction. Scientific herald of Lviv National University of Veterinary Medicine and Biotechnologies named after SZ Gzhytskyi. 2010;2 (44):214-8).
  6. 6. Nechyporuk VM, Korda MM. Metabolism in hypo- and hyperthyroidism. Herald of Scientific Research. 2015;3:4-7. 10.11603/1681-276Х.2015.3.5170
  7. 7. Chung H. Iodine and thyroid function. Annals of pediatric endocrinology & metabolism. 2014;4:8-12. 106065/apem.2014.19.1.8.
  8. 8. Desai J, Vachhani UN, Modi G, Chauhan K. A study of correlation of serum lipid profile in patients with hypothyroidism. International Journal of Medical Science and Public Health. 2015;8:1108-12. doi: 10.5455/ijmsph.2015.18032015234. doi.org/10.5455/ijmsph.2015.18032015234
  9. 9. Grantham JP, Henneberg M. The estrogen hypothesis of obesity. The Estrogen Hypothesis of Obesity. 2014; 6: 1-7. doi:10.1371/journal.pone.0099776. doi.org/10.1371/journal.pone.0099776
  10. 10. Kamyshnikov VS. Handbook of clinical and biochemical studies and laboratory diagnosis. MEDpress-inform. 2004: 920.
  11. 11. Kok-Yong C, Soelaiman I, Isa N. The relationships between thyroid hormones and thyroid-stimulating hormone with lipid profile in blood. Int J Med Sci. 2014; 4: 349-55. doi.org/10.7150/ijms.7104
  12. 12. Kopchak NH, Pokotylo OS, Kukhtyn MD, Koval МІ. Influence of iodine on the indicators of lipid profile of rats' blood of different age in experimental obesity. Medical and Clinical Chemistry. 2017;4:123-8. doi.org/10.11603/mcch.2410-681X.2017.v0.i4.8437
  13. 13. Mamenko MYe. Prevention of iodine deficiency disorders: what should know and can do a pediatrician and general practitioner? (Clinical practice guideline). Modern Pediatrics. 2017;82:8-16. doi.org/10.15574/SP.2017.82.8
  14. 14. The method of modeling of alimentary obesity. Patent Ukraina, No u 2013 12044, 2014.
  15. 15. Nykolyshyn LV. Peculiarities of lipid profile of blood, Microelement balance in hypothyroid dysfunction, possible ways of correction. Galic'kij Likars'lij Visnik. 2014;1:49-53.
  16. 16. Pokotylo OS, Yanovich VG. Lypogenesis and cholesterinogenesis in the liver of rats at cholesterol loading. Ukrain'skyi Biokhimichnyi Zhurnal. 2008;80(1):68-72.
  17. 17. Ramachandran K, Ebenezer W, Thangapaneer S, Shyam K. Relationship between lipoprotein(a) and thyroid hormones in hypothyroid patients. Journal of Clinical and Diagnostic Research. 2014;2:37-9. doi.org/10.7860/JCDR/2014/7817.4001
  18. 18. Raziel A, Rosenzweig B, Botvinic V. The in- fluence of thyroid function on serum lipid profile.1982;2:321-6. doi.org/10.1016/0021-9150(82)90196-4
  19. 19. Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. The open: Cardiovascular Medicine Journal. 2011;5:76-84. doi.org/10.2174/1874192401105010076
  20. 20. Russo GT, Giandalia A, Romeo EL, Cucinotta D. Gender differences in lipoprotein metabolism. Ital J Gender-Specific Med. 2015;2:58-65. doi.org/110.1723/2188.23640
  21. 21. Shashi A. Lipid profile abnormalities in hypothyroidism. International journal of Science and Nature. 2012;2:354-60. 22. Yuzvenko TYu. Correlation of hypothyroidism and obesity. International endocrinology Journal. 2016;8:11-4. doi.org/10.22141/2224-0721.8.80.2016.89530


Програмування - Roman.im