online ISSN 2415-3176
print ISSN 1609-6371
logoExperimental and Clinical Physiology and Biochemistry
  • 5 of 11
Up
ECPB 2018, 84(4): 31–34
https://doi.org/10.25040/ecpb2018.04.031
Research articles

The Role of Cholecalciferol in the Reduction of Insulin Resistance and Rehabilitation of Women with Primary Hypothyreosis

O.S. PAYENOK 1, I.V. PANKIV 2, A.V. PAYENOK 1
Abstract

Background. Vitamin D deficiency is one of the risk factors for insulin resistance and there is a relationship between hypovitaminosis of vitamin D with the prevalence of primary hypo- Experimental and clinical physiology and biochemistry, ECPB 2018, 4(84): 31–34. https://doi.org/ 34 Experimental and clinical physiology and biochemistry, ECPB 2018, 4(84): 31–34. https://doi.org/ thyroidism. The effect of cholecalciferol supplementation on insulin resistance in women with primary hypothyroidism has not been investigated before. The aim of the study is to evaluate the role of cholecalciferol supplementation on insulin resistance in primary hypothyroidism. Materials and methods. 72 women, aged 31-75 took part in the study. Serum thyroid stimulating hormone (TSH), insulin and 25(OH)D concentration were measured and HOMA-IR was calculated. All measurements were performed at the beginning and the end of the study. Women with hypothyroidism had been receiving 21.000 unit of cholecalciferol orally per week during twelve weeks. The results were analyzed by descriptive tests and the comparison between variables was made by using paired T-tests. Results. All participants had vitamin D deficiency. Mean serum 25(OH)D concentration was 21.94 ± 6.31 ng/ml. The results at the beginning and at the end were for insulin 18.37 ± 2.48 and 10.19 ± 2.13 mIU/L (p = 0.041) and for HOMA-IR, 3.97 ± 0.36 and 2.32 ± 0.18 (p = 0.039), respectively. Conclusion. Vitamin D deficiency is common in women with primary hypothyroidism. Our data have shown some significant improvement in serum insulin and in HOMA-IR after treatment with cholecalciferol. Recieved: 30.11.2018

Keywords: hypothyroidism, women, insulin resistance, cholecalciferol, rehabilitation

Full text: PDF (Eng) 206K

References
  1. 1. Wang J, Lv S, Chen G, Gao C, He J, Zhong H et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 2015;7:2485-98. doi.org/10.3390/nu7042485
  2. 2. Mackawy AMH, Al-ayed BM, Al-rashidi BM. Vitamin D deficiency and its association with thyroid disease. International Journal of Health Sciences. (Qassim). 2013;7(3):267–275.
  3. 3. As Al-Shoumer K, Al-Essa TM. Is there a relationship between vitamin D with insulin resistance and diabetes mellitus. World Journal Diabetes. 2015;6(8) :1057-64 doi.org/10.4239/wjd. v6.i8.1057  
  4. 4. Toulis K, Tsekmekidou X, Potolidis E, Didangelos T, Gotzamani-Psarrakou A, Zebekakis P. et al. Thyroid autoimmunity in the context of type 2 diabetes mellitus: implications for vitamin D. International Journal Endocrinoly. 2015;710363. doi.org/10.1155/2015/710363
  5. 5. Palomer X, Gonzalez-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes, Obesity and Metabolism. 2008;10:185–197. doi.org/10.1111/j.1463-1326.2007.00710.x
  6. 6. Díez JJ, Iglesias P. An analysis of the relative risk for hypothyroidism in patients with Type2 diabetes. Diabetic Medicine. 2012;29(12):1510-14. doi.org/10.1111/j.1464-5491.2012.03687.x.
  7. 7. Duntas LH, Orgiazzi J, Brabant G. The interface between thyroid and diabetes mellitus. Clinical Endocrinology. 2011;75(1):1-9. doi.org/10.1111/j.1365-2265.2011.04029.x  
  8. 8. Von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resis-tance in south Asian Women living in New Zealand. Br J Nutr. 2009;28:1-7.
  9. 9. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in non-diabetic adults. Diabetes Care. 2007;30(4):980-86. doi.org/10.2337/dc06-1994
  10. 10. Witham MD, Dore FJ, Druburgh M, Sugden JA, Morris AD, Struthers AD. The effect of different doses of vitamin D3 on markers of vascular health. Diabetologia. 2010;53(10):2112-19. doi.org/10.1007/s00125-010-1838-1
  11. 11. Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabetic Medicine. 2009;26(1):19-27. doi.org/10.1111/j.1464- 5491.2008.02636.x.  
  12. 12. Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE. Expression of 25-hy- droxyvitamin D3-1alpha-hydroxylase in pancreatic islets. Journal of Steroid Biochemistry and Molecular Biology. 2004;89–90(1–5):121-5. doi.org/10.1016/j.jsbmb.2004.03.115


Програмування - Roman.im