The functional state of vessels could lead to the appearance of many diseases in different systems of the body and to a large extent determines the life expectancy. However, the initial stages of vessels injury do not have the specific clinical features as usual. Steam from this, the detection of endothelial dysfunction and its causes on early stages in young people, is a main task for scientists and doctors.

It is well known, that a lot of pathotological conditions in our body have a connection with the dysfunction of autonomic nerve system (ANS). That is why the aim of our study was to examine the relationship between functional condition of ANS and endothelium among young men with different state of ANS.

The subject of the study was 31 young healthy men ages from 18 to 25. To test the endothelium dependent vasodilatation was used non-invasive method with occlusion test and reactive hyperemia. The heart rate variability (HRV) was measured by using device ‘Cardiolab’ (Ukraine).

Multiple regression analysis was conducted to examine the relationship between HRV and functional condition of endothelium. According to the multiply regression analyses we found statistically significant predictors, which influence on functional state of endothelium. They were LFnorm, % (b = 0,4842, р < 0,012), LF/HF(b = 6,6882, р < 0,0001) and IC (b = -1,3466, р < 0,045), HF, % (b = -0,5364, р < 0,005) та HFnorm, % (b = -0,6074, р < 0,010). The major influence on functional state of endothelium had LF/HF (b* = 1,5045). The linear regression was constructed to illustrate the he relationship between the conditional independent parameter (LF / HF) and the dependent parameter of endothelial function, since practically all experimental points are as close as possible to the direct.

The structure of the initial vegetative tone is determined according to the results of the spectral analysis of the HRV, as well as the values of TP and HF. The major part of examined men had normotonic type of autonomic regulation (45,2 %), 32,3 % – had sympathetic type of autonomic regulation and 22,6 % – parasympathetic one. The next step was to compare the endothelial function between these three groups by nonparametric method (ANOVA). The results of statistical analyses indicated that in group of normotonic autonomic regulation was observed normoergic type of the reaction of the brachial artery to the performed test (15,86 ± 6,40), but in groups with autonomic dysfunction were observed pathological type of the reaction of the brachial artery to the performed test. For example, in group of sympathetic type of autonomic regulation was observed hyperergic type of reaction of brachial artery (28,33 ± 17,30 %), in group of parasympathetic autonomic regulation was observed hypoergetic type of reaction of brachial artery in perfomed test (10,46 ± 4,59 %). The difference in the alteration of diameter of brachial artery was significant between three groups (р < 0,005).

The results illustrate that alteration in HRV could be consider as predictors of endothelial dysfunction.

Recieved: 23.01.2019

Keywords: autonomic nervous system; autonomic dysfunction; heart rate variability; endothilium dysfunction; endothelium dependent vasodilatation

Full text: PDF (Ukr) 445K

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