Inroduction. Endogenous intoxication is a nonspecific syndrome that is characteristic of many diseases. The prognosis of the course of various toxic conditions, many diseases that are accompanied by an intoxication syndrome, the choice of the method of detoxification therapy and other forms of treatment is difficult without the objective assessment of the degree of endogenous intoxication. The determination of the average mass and the erythrocytic index of intoxication in the blood allows to assess the degree of endogenous intoxication as well as to control the effectiveness of detoxification procedures. The acute adrenalin myocardium damage leads to the increase in the level of middle mass molecules. The purpose of our study was to determine the state of endogenous intoxication by the level of middle mass molecules and the erythrocytic index of intoxication in the blood of rats in the dynamics of the adrenalin myocardium damage. Materials and methods. The experiments were carried out on white male rats of Wistar line with the weight 180-200 grams, which were divided into 4 groups of 10 animals (one control group and three tested ones). The adrenalin myocardium damage was induced on the 1st, 3rd and 5th day of the experiment, after which MSM254 and MSM 280 and the erythrocytic index of intoxication were determined. Results. The condition of endogenous intoxication (EI) was estimated at the level of MSM254, MSM280 and EI in the blood, which were determined at different periods (1st, 3rd and 5th day) in the dynamics of the development of acute APM in rats. Under the conditions of APM, the increase in the content of MSM254 was observed by 1,2 (p < 0,05) and MSM280 by 1,5 (p < 0,05) in the experimental group 2 respectively, during the 1st day after the APM as compared with the control one. After the administration of adrenalin, the level of MSM254 has increased by 0,8 (p < 0,05) while MSM280 has increased by 1,1 (p < 0,05) in the experimental group 3 on the 3rd day of the experiment in comparison with the intact group of animals. The experimental group 4, on the 5th day of the APM has been characterized by the increase in the content of MSM254 by 0,5 (p < 0,05) and in the content of MSM280 by 0,8 (p < 0,05) as compared with the control one. Another indicator of EI in the blood during the first day of the experiment in the experimental group 2 has increased by 87.54 % (p < 0.05) in the APM as compared with the intact group. This figure during the 3rd day of the experiment has increased by 78,88 % (p < 0,05) in the experimental group 3 in comparison with the control one. In the experimental group 4, there was the increase of EI by 50.31 % (p < 0.05) as compared with the control one. Conclusions. The complex biochemical studies of indicators of endogenous intoxication in animals of different groups (the intact one and the group with acute adrenalin myocardium damage) on the 1st, 3rd, 5th day have proved that there is a consistent excessive formation of products of endogenous intoxication at all stages of their formation. Especially on the 1st day of the experiment with the gradual decrease in endogenous intoxication during the 5th day in comparison with the control group in which the development of the acute myocardial ischemia was indicated.
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