Introduction. Earlier in the experiments in rats and in clinical observations showed that the immune responses to chronic stress are ambiguous and individual. Adaptogens, in particular balneofactors, are antipodes of stressors. The immune responses to balneotherapy are also ambiguous. Therefore, the purpose of this study is to analyze variants of immune responses to balneofactors of Truskavets’ spa as natural adaptogens and to determine the possibility of their prediction. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets’ spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. The survey was conducted twice, before and after balneotherapy (drinking bioactive water Naftussya three times a day, ozokerite applications, mineral baths every other day for 7-10 days). Immune status evaluated on a set of I and II levels recommended by the WHO as described in the manuals. In portion of capillary blood we counted up Leukocytogram and calculated two variants of Adaptation Index as well as two variants of Strain Index by IL Popovych. We calculated also the Entropy of Immunocytogram and Leukocytogram. The condition of microbiota is evaluated on the results of sowing of feces and urine. Results. Four variants of the immune responses to adaptogenic balneotherapy have been identified. In 40,9% of patients, initially normal immune status did not change significantly. In 31,8%, the lower boundary level of immunity is completely normalized. In 22,7% moderate immunosuppression is reduced, but not up to normal. However, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. All four variants of immune responses are virtually unmistakably predicted by a set of 20 predictors, which allows us to make adjustments to balneotherapy in advance. Conclusion. Immune responses to adaptogens are individual and conditioned by a number of predictors.
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