The analysis of theoretical and applied aspects of the application of alternative methods of toxicity research in the implementation of hygienic regulation of chemical production factors and the prospects of their use in Ukraine showed that scientific developments on the replacement of vertebrates in experiments on the study of chemical toxicity in both European countries and other countries great attention is paid to and significant support from state regulators. Validated alternative toxicity research methods are available in publicly available databases and cover virtually all types of toxic effects. In Ukraine, insufficient attention is being paid to this issue at the state level. The European vector of development of Ukraine obliges the state and scientists to actively introduce alternative methods of research in the field of industrial toxicology.
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