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ECPB 2020, 90(2): 64–67

Polymorphisms of paraoxonase genes – the common background of gallbladder and heart diseases


Paraoxonases are produced by liver. These enzymes hydrolize and detoxify oxidized low density lipoproteins and homocysteine and have an important value in atherosclerosis development. With the aim of estimation the modern points of view onto the role of paraoxonase genes mutations in te development of cardiovascular and hepatobiliary disorders we made a literature search. It was revealed that paraoxonases are produced by liver and are associated with high density lipoproteins, hydrolize and detoxify oxidized low density lipoproteins and homocysteine. That’s why their decrease leads to the high risk of development of atherosclerosis, diabetes mellitus, cholelithiasis, age-related diseases, and metabolic syndrome. Polymorphisms of genes of paraoxonase 1 (PON1-Q192R; -gln191 to arg; PON1-L55M (LL, MM, LM); G-907C, A-162G and C-108T), paraoxonase 2 (Ala/Gly in 148 position and Ser/Cys in 311 position) and paraoxonase 3 (c.449G >A, SNPs A10340C, A2115T and introne variant of PON3 INS2+3651(A>G)(rs10487132)) are associated with cardiovascular and biliary diseases independently of lipid profile and smoking status due to activation of the oxidative stress and inflammation. Polymorphisms of paraoxonase genes are the common genetic background of heart and gallbladder disorders.

Added: 20.05.2020

Keywords: paraoxonases, genetic polymorphism, cardiovascular diseases, cholelithiasis, biliary diseases

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