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ECPB 2020, 91(3): 20–25
Research articles

Physiological features of leptin in patients with diabetes type 2 and eating disorders


The main method of achieving the target levels of lipids and blood sugar in patients with diabetes type 2 (DT2) is healthy diet and physical exercises. The vast majority of patients with DT2 suffer from overweight or obesity. The presence of eating disorders (ED), such as binge-eating (BE) and night eating syndrome (NES), is an obstacle in the treatment of these patients. Leptin is the hormone of white adipose tissue which binds with proopiomelanocortin (POMC) receptors in the hypothalamus and activates satiety centre. It leads to decreasing of the feeling of hunger and inhibition of eating behavior. In patients with DT2 and obesity the level of leptin is increased due to the positive energy balance and efforts of the organism to stop overeating. The aim of our study was to determine the levels of leptin and its impact on food center in overweight/obese DT2 patients and its association with ED. To achieve this goal we examined 57 overweight or obese patients with DT2, each of whom completed Questionnare on eating and weight patterns-5 and Night Eating Diagnostic Questionnaire. 19 patients showed positive results for BE or NES. Patients were divided into 2 groups: group 1 – patients with DT2, group 2 – patients with DT2 and ED. The control group consisted of 14 healthy volunteers with a body mass index (BMI) > 25 and negative results for BE or NES. Leptin levels were significantly (p<0,05) higher in the group with ED comparing to the 1st study group and control group. We assume, that high leptin levels in patients with ED describe the broken central regulation of eating behavior. Investigation of food-related hormones can probably help in developing new anti-obesity and anti-diabetic medications.

Recieved: 02.09.2020

Keywords: diabetes, obesity, leptin, eating disorders

Full text: PDF (Ukr) 334K

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