In order to study changes in the activity of secretory serum enzymes in patients with generalized periodontitis (GP) as a result of comprehensive treatment, there were examined 36 healthy persons and 132 patients with GP with chronic and acute course of the initial (45), the I st (45) and the II nd (42) degree of the disease, somatically healthy, aged 19-45 years. The activity of cholinesterase (CE) and ceruloplasmin (CP) was studied before, immediately after, after 6 and 12 months. There was a decrease in the activity of CE in GP of the initial degree, especially in the case of exacerbation (p 1 <0.05), and after treatment it significantly increased in all patients (p 2 <0.05–0.005) and became higher than normal. Instead, the activity of CP was increased, and due to the therapy it significantly decreased for six months and was close to normal. In the I st degree of the disease, the activity of CE was even lower, and the CP – was much higher. The normalization of activity was achieved by the treatment, especially immediately after it and after 6 months. The decrease in CE and increase in CP indices in GP of the II degree was the largest (p 1 <0.01–≤0.001). The treatment contributed to a significant increase in the activity of CE in the chronic course for the whole year, in the acute course – for six months, as well as a significant reduction in CP in the chronic course for six months, and in the acute course – for a year. The difference with the healthy people after therapy in all patients was insignificant. Strong reliable inverse correlations were found between the activity of CE and CP at all stages of the study. Therefore, significantly altered activity of CE and CP with the use of spirulina is successfully regulated, especially during the first six months, with the achievement of the norm for GP of the initial and I st degree.
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