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ECPB 2015, 69(1): 46–50
https://doi.org/10.25040/ecpb2015.01.046
Clinical physiology and biochemistry

Diagnostic importance of hyperuricemia in cardiovascular disease

PYLYPIV O., SKLYAROVA О.
Abstract

The interrelation between uric acid levels and the most common predictors of the risk of cardiovascular disease in patients with hypertension were studied. The study involved 74 patients with hypertension (37 women and 37 men) aged 30–78 years (mean age 59,7 ± 1,7 years). Verification of stage and degree of hypertonic disease was based on physical, clinical, instrumental examination and in according to classifications recommended by the Ukrainian Association of Cardiology (2007).

The degree of obesity was assessed according to the criteria of International Diabetes Federation (IDF, 2005) based on the determination of body mass index (BMI). Among the surveyed patients, 9 persons were of normal weight, 22 overweight, 32 with rthe first degree of obesity, 8 with second degree of obesity and 3 with third degree. The average body mass index was equal to 30,8 ± 0,7 kg/m2.

All patients went through general clinical examination, echocardiography, ultrasonic research of internal organs, examination of blood lipid spectrum, LDL cholesterol, HDL cholesterol, triglycerides, creatinine, γ-glutamyl transpeptidase and uric acid. The interrelation between uric acid levels and the most common predictors of the risk of cardiovascular disease was analyzed in accordance with the intended purpose of the study in general population of patients (74 people), by gender (37 men/37 women), considering the level of uric acid (< 360> mmol/l).

Patients were divided by the level of uric acid, regardless of gender, into 2 groups: the 1– patients with content of uric acid < 360 mmol/l (N = 29) and the 2 – patients with uric acid level > 360 mmol/l (N = 45).

It was established that 74 patients had mean value of uric acid 405,7 ± 17,0 mmol/l, although almost 40 % of the uric acid levels did not go beyond the norm. Among possible risk factors of hyperuricemia in this group of patients except the main disease - hypertension – should be noted the age 59,7 ± 1,7 years, overweight and obesity in 84% of cases (BMI – 30,85 ± 0,71 kg/m2), increased total cholesterol (6,0 ± 0,14 mmol/l), low density lipoprotein cholesterol (3,8 ± 0,11 mmol/l), triglycerides (2,23 ± 0,11 mmol/l). The average concentrations of creatinine (95,3 ± 3,7 mmol/l) and γ-glutamyl transpeptidase (43,1 ± 3,4U/l) were within the normal range. Correlation interconnections between uric acid and triglycerides (r = 0,35), triglycerides and creatinine (r = 0,30) and between uric acid and creatinine (r = 0,51) were obtained.

A significant increase of uric acid (440,86 ± 22,99 mmol/l) at a younger age (55,06 ± 2,23 years) were observed in men, compared with the women`s values of uric acid (370,54 ± 23,92 mmol/l), whose average age was equal to 63,62 ± 1,99 years. On the other hand, in women was observed a correlative interrelation between triglycerides and uric acid, triglycerides and creatinine and uric acid and creatinine, whereas in men such interrelations were not found.

Thus, the obtained data indicate the clear correlations between high levels of plasma triglycerides with the values of creatinine and uric acid in women. On the contrary, the same correlations in men were not noted, however, hyperuricemia occurs at the earlier age than for women.

Finally, there are gender development features of hyperuricemia, which determines for women a correlation between triglycerides and uric acid, creatinine and uric acid, triglycerides and creatinine. For men hyperuricemia comes up 8 years earlier than for women. Further research is required to establish the mechanisms of men’s hyperuricemia.

Keywords: hyperuricemia, hypertension, cardiovascular disease

Full text: PDF (Ukr) 804K

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