Currently, the clinical significance of the hemoglobin-to-creatinine (Hb/ Cr) ratio in patients with chronic forms of coronary artery disease (CAD) and arterial hypertension (AH) remains undetermined. Furthermore, its potential utility in the outpatient management of these individuals has not been fully explored, highlighting the relevance and necessity of this study.

Aim: To evaluate the hemoglobin-to-creatinine ratio in patients with chronic coronary artery disease and arterial hypertension, and to analyze its clinical correlations.

Materials and Methods. In compliance with the Declaration of Helsinki and following informed consent (Bioethics Committee Approval No. 2, Danylo Halytsky Lviv National Medical University, dated February 21, 2022), 53 outpatient men (mean age 57.4 ± 1.3 years) with chronic CAD and AH were examined. In addition to standard protocol assessments, fibrin monomers, D-dimer, and platelet aggregation activity (PAA) were measured. The de Ritis ratio and the hepatic steatosis index were calculated as markers of liver steatosis. Statistical analysis was performed using mathematical methods, with data presented as mean ± standard error (M ± m). The significance level was set at p < 0.05.

Results. The mean Hb/Cr ratio for the entire cohort was 1.53 ± 0.05. A decrease in this ratio was identified as an unfavorable sign, being accompanied by a progression in the functional class of chronic heart failure (HF), increased platelet aggregation, elevated fasting blood glucose, and left ventricular dilation associated with a reduced ejection fraction (all p < 0.05). Significantly lower values of the Hb/Cr ratio were observed in patients with uncontrolled arterial hypertension, higher heart failure functional classes, reduced ejection fraction, left ventricular dilation, as well as elevated erythrocyte sedimentation rate (ESR) and increased platelet aggregation activity.

Conclusion. The hemoglobin-to-creatinine ratio in patients with chronic coronary artery disease and arterial hypertension was 1.53 ± 0.05. A reduction in this ratio serves as an unfavorable clinical indicator.

Keywords: hemoglobin-to-creatinine ratio, coronary artery disease, arterial hypertension, heart failure, ejection fraction